NAD+ is a coenzyme your cells need to convert nutrients into ATP—usable energy. Without sufficient NAD+, this process fails. By 50, you have half the NAD+ you had at 20. By 80, you're down to 20%.

When NAD+ declines, every system in your body functions worse. Muscles can't repair efficiently. Brain cells struggle to maintain focus and memory. Immune response slows. Skin cells turn over slower, creating visible aging. It's one root problem affecting everything.

If NAD+ decline drives cellular dysfunction, restoring NAD+ levels reverses it. Mice given NAD+ precursors live longer with better physical function. Human studies show increased NAD+ levels improve muscle function, insulin sensitivity, cognitive performance, and recovery.

The challenge is delivery. NAD+ molecules are too large to absorb directly. You need precursors—smaller molecules that convert to NAD+ inside your cells.

You have two options for increasing NAD+. Both work through different pathways. NMN converts directly to NAD+ in one step. NR converts to NMN first, then to NAD+. Your genetics determine which works better.

NR (Nicotinamide Riboside)

Start with NMN for single daily dosing. The sublingual method provides faster absorption.

Start with NR if you prefer capsules and splitting doses. Twice-daily maintains steadier levels.

If one doesn't work after 6 weeks at maximum dose, switch to the other. Don't take both—pick one pathway.

Human studies on NAD+ precursors demonstrate:

These are real but modest effects. You're restoring cellular function, not reversing time.

Most responders notice changes around week 3-4. Morning energy improves. Recovery from exercise speeds up. Afternoon fatigue decreases. Mental endurance increases—you can focus longer without brain fog.

By week 6-8, full effects manifest. Energy stays stable throughout the day. Physical tasks feel easier. Some report better skin quality—improved hydration, faster wound healing.

NAD+ supplementation works best for people over 40 with unexplained fatigue. If you sleep well, eat well, exercise, but still feel drained, you're a good candidate.

Athletes benefit from faster recovery. People under chronic stress see improvements because stress depletes NAD+ faster. Those concerned with skin aging notice subtle improvements over months.

NAD+ won't make you feel 20 again. It won't cure diseases. It won't replace exercise, sleep, or proper nutrition. It won't dramatically change your appearance.

It will restore some cellular energy production lost with age. For many, that's enough to feel significantly better.